Background: Morphea is a rare sclerosing disorder characterized by the formation of erythematous to violaceous lesions and sclerotic plaques on the skin that can extend to the reticular dermis and subcutaneous tissue. This condition may be associated with pain, pruritus, and limitations in range of motion, causing significant disruption in patients’ quality of life. Similar sclerosing disorders, such as eosinophilic fasciitis and systemic sclerosis, have been associated with hematologic diseases like aplastic anemia (AA). However, few reports of morphea in association with AA have explored this relationship. Case presentation: A 29-year-old woman with a history of AA presented with pruritic, indurated hyperpigmented plaques on her lower extremities. Her past medical history included congenital aortic stenosis and focal epilepsy. A skin biopsy was consistent with morphea. A concurrent bone marrow biopsy confirmed persistent hypocellularity consistent with AA. Conclusion: This case highlights a potential immunologic link between morphea and AA given that both diseases involve dysregulated T cell-mediated immune responses. We explore a potential immunologic connection between the two conditions, including the role of chemokines, such as CXCL10, in their pathogenesis. Additionally, we discuss important considerations for physicians when evaluating patients with morphea.
Soto-Canetti et al. (Sun,) studied this question.
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