Obesity Treatment With Bariatric Surgery vs GLP-1 Receptor Agonists

Importance Obesity is a chronic condition with negative consequences for patients, the health care system, and society. The most effective treatment of class II and III obesity is metabolic bariatric surgery (MBS), which is usually considered a last resort. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have recently shown promising results. Objective To compare weight loss and ongoing costs associated with MBS and GLP-1 RAs in the US. Design, Setting, and Participants This cohort study used data from the Highmark Health insurance claims database and the Allegheny Health Network electronic medical record in the US. Participants were patients with class II or III obesity treated with either MBS or GLP-1 RAs who were enrolled in Highmark insurance for at least 6 months prior to index treatment and had follow-up data available for at least 12 months. Using propensity score weighting, the populations were adjusted for differences in baseline spending, health care utilization, age, sex, comorbidities, and smoking status. Data were analyzed from July 2024 to July 2025. Exposures MBS (sleeve gastrectomy or gastric bypass) vs GLP-1 RAs (dulaglutide, exenatide, liraglutide, lixisenatide, semaglutide, or tirzepatide). Main Outcomes and Measures The main outcomes were total weight loss and monthly ongoing costs (pharmacy, medical, and surgery costs) at baseline and over 2 years after index treatment. Mean adjusted costs were calculated using a linear mixed-effects model. Results Analyses included 30 458 patients (mean SD age, 50 11 years; 20 118 66. 1% female), with 14 101 undergoing MBS (mean SD follow-up, 34 16 months) and 16 357 receiving GLP-1 RAs (mean SD follow-up, 32 17 months). After propensity score weighting, baseline characteristics were comparable. The mean (SE) total costs over 2 years were 63 483 (1563) for GLP-1 RAs and 51 794 (1724) for MBS (P lt;. 001). The main driver of this difference was higher sustained pharmacy costs in the GLP-1 RA group throughout year 2 of follow-up. Comparing weight loss data of 257 patients using GLP-1 RAs and 1291 patients who underwent MBS, total weight loss was greater for the MBS group (mean SE, 28. 3% 0. 3%) than the GLP-1 RA group (mean SE, 10. 3% 0. 5%) (P lt;. 001). Conclusions and Relevance These findings suggest that MBS was associated with more weight loss at lower ongoing costs compared with GLP-1 RAs in class II and III obesity. Further study is needed to determine if MBS should still be considered the last resort in treating obesity.