The founder of Homoeopathy, Master Hahnemann boldly took the first step. It is emphasized in 6th edition that the dry dose is the weakest dose. For those who wish to give the “One dose high” try putting high potency into liquid solution and succussions 8-10 more times before the next dose. This follows main principles of the 6th edition of Organon of Medicine.
Boricha et al. (2025) studied this question.