Abstract B105: Interim analysis of the research navigator-led PRE-ACT educational intervention to promote decision making about clinical trials among racial and ethnic minorities

Abstract Background Recruiting diverse patient populations for clinical trials remains a challenge. PRE-ACT is a web-based patient tailored educational tool, previously demonstrated in a randomized controlled trial to improve knowledge and decrease attitudinal barriers to clinical trials participation. However, the PRE-ACT study enrolled a predominantly white population and subgroup analysis did not show benefit among the non-white participants. The primary objective of this study was to improve preparation for consideration of clinical trials using tailored, patient-specific information to address knowledge and attitudinal barriers among racial/ethnic minority cancer patients. This intervention adapted the PRE-ACT model and incorporated the use of research navigators to provide in-person direct education in addition to video-based content. Here, we report the interim analysis of study data. Methods This is an ongoing interventional cohort study. Patients were 18 or older, had a diagnosis of cancer undergoing oncological work-up, treatment, or surveillance, self-identified as non-white race or Hispanic ethnicity, and had a life expectancy 3 months. Demographic and socioeconomic status indicators were collected by survey. Knowledge and attitudes towards clinical trials were assessed by survey before and after the educational intervention. The intervention included an in-person, research navigator-facilitated 30-minute educational encounter including videos and discussion tailored based on pre-intervention survey responses. Patient characteristics and survey results are described using descriptive statistics. Results At the time of interim analysis, 94 patients were enrolled in the study and 41 had completed the post-intervention survey. Median age was 66 years (range 27-86). Majority of patients were female (59%) and identified as African American/Black race (93%). Only 3% identified as Hispanic or Latino. The most common cancer types included lung (62%) and breast cancer (25%) with other cancer types including prostate and colon cancer. The majority had metastatic disease. Common knowledge gaps included placebo, informed consent, randomization in a clinical trial, and current underrepresentation in clinical trials. After the intervention, most patients (86%) could identify resources to learn more about clinical trials. Additionally, most patients (85%) reported they would be more likely to consider clinical trials as a potential treatment option as a result of the intervention. Conclusions Novel strategies are needed to improve consideration of clinical trials among racial/ethnic minorities. We adapted the PRE-ACT model and utilized research navigators to promote engagement in the assessment of barriers to participation in clinical trials among minority cancer patients. This interim analysis describes common knowledge gaps among patients. Future analysis will compare changes in knowledge and attitude scores before and after the intervention. Citation Format: Annie L. Zhang, Petrina Patterson, Deyanna Decatur, Seunghee Margevicius, Debora Bruno, Lauren Chiec. Interim analysis of the research navigator-led PRE-ACT educational intervention to promote decision making about clinical trials among racial and ethnic minorities abstract. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr B105.