Identification of Molecular Signatures and Prognostic Markers in Clear Cell Renal Cell Carcinoma through Advanced Bioinformatics and Systems Biology

This study aimed to find potential genes that could serve as biomarkers for the diagnosis, prognosis, or targeted therapy of clear cell renal cell carcinoma (ccRCC). Two expression profiles, GSE36895 and GSE53757, were taken from Gene Expression Omnibus. Differentially regulated genes (DRGs) between clear cell renal cell carcinoma (ccRCC) and normal tissues were identified using GEO2R. The analysis yielded 409 upregulated and 125 downregulated genes (adjusted p-value 1). Overall, the study findings highlight novel gene candidates with potential clinical significance. The identified hub genes may serve as prognostic indicators and possible therapeutic targets, contributing to improved clinical management of ccRCC in the future.