An Endoplasmic Reticulum-Targeted NIR-II Type I AIE Photosensitiser for Triggering Pyroptosis

Key Points

• The endoplasmic reticulum-targeted photosensitizer successfully induces pyroptosis.
• Type I ROS generation was confirmed, enhancing the effectiveness of the therapy.
• Nanoparticles were used for efficient internalization and targeted delivery of the photosensitizer.
• Results indicate significant promise for this strategy in cancer treatment methods.

Abstract