Background: Pancytopenia is a common hematological condition characterized by the simultaneous reduction in all three blood cell lines: erythrocytes, leukocytes and, thrombocytes. The present study investigates the etiology, clinical presentations, and outcomes of pancytopenia in patients admitted to the Rajshree Medical Research Institute in Bareilly, Uttar Pradesh, from June 2022 to May 2024. Material & Methods: All cases presenting with pancytopenia on peripheral blood were included in the study after IEC clearance. (IEC/IRB No: 035/2022) dated 10 September 2022. Patients refusing to give valid consent were left out from the study. Simultaneously, bone marrow examination and serum values were carried out to reach to a proper diagnosis. Results: A total of 88 cases of pancytopenia were analyzed, with important causes identified as megaloblastic anemia, aplastic anemia, malaria and hypersplenism. The study found a higher prevalence of pancytopenia in females as compared to the males, with the most affected age group being 10-20 years. Clinical presentations varied, with fatigue, pallor, and fever being the most frequent symptoms. Conclusion: The study highlights the importance of thorough clinical and laboratory evaluation to determine the underlying cause of pancytopenia and guide appropriate management and treatment strategies. Keywords: Pancytopenia, Bone marrow, Megaloblastic Anaemia, Aplasia
Agrawal et al. (Fri,) studied this question.