Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-related fatalities, and there are no available specific therapies. The pathophysiology of the condition is not straightforward and is poorly understood. A 2-hit model is generally attributed to underlie TRALI. In this case report, we report a case of a 72-year-old male patient with no significant history, who was transfused with packed red blood cells and developed TRALI as a consequence. He recovered in 24 h and had no sequelae. Laboratory investigations of the blood donors revealed a positive human leukocyte antigen antibody screen. Further research is required to comprehend and elucidate the pathophysiology of TRALI, for better diagnostics and therapeutic approaches for the same in the future.
Balachandra et al. (Fri,) studied this question.