Objective: To synthesize evidence from randomized controlled trials (RCTs) and quasiexperimental studies evaluating the effectiveness of nurse‐led interventions on health outcomes in adults and older adults with multimorbidity. Background: Multimorbidity presents complex healthcare challenges and worsened outcomes, especially in older adults. Nurse‐led interventions are emerging as a strategic model to address these needs. Evaluating their effectiveness is essential for advancing evidence‐based chronic care. Design: A systematic review guided by the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. Methods: Two reviewers independently screened studies according to refined inclusion criteria. Risk of bias was assessed using the Risk of Bias 2 tool for RCTs and the ROBINS‐I tool for quasiexperimental studies. Data were synthesized using a convergent integrated approach, following the Joanna Briggs Institute methodology. Data Sources: Nursing & Allied Health Collection (ProQuest), PubMed, MEDLINE, ScienceDirect, and Scopus. Results: Thirteen studies met the inclusion criteria. Nurse‐led interventions, delivered in person, via telephone, or through digital platforms, were effective in improving care quality, medication adherence, self‐management, self‐efficacy, and select biophysical indicators such as blood pressure and glucose levels. Some studies also reported reductions in hospital readmissions and mortality. Thematic synthesis revealed four major domains of benefit: health outcomes, self‐management and adherence, health functioning, and support and healthcare utilization. Conclusion: Nurse‐led interventions contribute to improved health outcomes in adults with multimorbidity by supporting adherence, self‐care, and key clinical indicators. These findings highlight the crucial role of nurses in delivering integrated, patient‐centered care, supporting their inclusion in chronic disease management strategies. Implications for the Profession or Patient Care: The results highlight nurses’ key role in coordinating and delivering effective care. By promoting self‐management and adherence, nurse‐led models serve as a foundation for managing complex chronic conditions. Broader implementation can improve outcomes and reduce healthcare burdens.
Ruksakulpiwat et al. (Wed,) studied this question.