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September 23, 2025

Computational approaches for the discovery of novel chromen-2-one derivatives as 5-HT1A inhibitors for the treatment of schizophrenia

SGShankar GuptaHemwati Nandan Bahuguna Garhwal University SMSatyabrata MaityUniversity of Calcutta ASAastha SinghIndo Soviet Friendship College of Pharmacy

Key Points

Novel chromen-2-one derivatives may effectively inhibit 5-HT1A activity, showing potential for schizophrenia therapy.
The study utilizes computational methods to discover inhibitory properties of these derivatives, aiming to improve treatment options.
The comprehensive approach not only identifies potential compounds but also lays groundwork for future schizophrenia drug development.
Implications can enhance understanding of molecular interactions and target more effective therapeutic strategies for this mental health disorder.

Abstract

Journal of Computational Biophysics and ChemistryAccepted Papers No AccessComputational approaches for the discovery of novel chromen-2-one derivatives as 5-HT1A inhibitors for the treatment of schizophreniaShankar Gupta, Subhadip Maity, Aastha Singh, Amena Ali, Abuzer Ali, Shubham Dhiman, and Vivek AsatiShankar Gupta, Subhadip Maity Search for more papers by this author , Aastha Singh Search for more papers by this author , Amena Ali Search for more papers by this author , Abuzer Alihttps://orcid.org/0000-0002-4313-3896 Search for more papers by this author , Shubham Dhiman Search for more papers by this author , and Vivek Asati Search for more papers by this author https://doi.org/10.1142/S2737416526500031Cited by:0 (Source: Crossref) PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetails Recommended Accepted Papers Metrics History Received 9 July 2025 Accepted 15 September 2025 PDF download

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