Cu–diamine ligand-controlled asymmetric Henry reactions and their application in concise total syntheses of linezolid and rivaroxaban

Key Points

• The method achieves high enantioselectivity in producing chiral nitroalcohols, enhancing synthetic versatility.
• Utilizing a Cu-bis(sulfonamide)–diamine complex, the reactions were optimized for carbamate acetaldehydes and nitromethane.
• Applications in concise total syntheses of linezolid and rivaroxaban highlight its potential in pharmaceutical chemistry.
• By achieving efficient chiral synthesis, this approach may streamline future drug development processes.