What type of study is this?

This is a Quantitative Study study (also classified as: Experimental Study).

September 27, 2025

Programmable Bimetallic MOF Nanozyme Composite with Microenvironment-Adaptive Cascade Catalysis for Wearable Glucose Biosensing and Accelerated Diabetic Wound Healing

Key Points

The nanozyme composite improves glucose monitoring and wound healing for diabetes management through innovative materials.
Using engineered MOF-919 with Fe/Cu sites, the device exhibits unique microenvironment-adaptive catalysis for increased efficacy.
The study employs biomimetic coencapsulation techniques to stabilize enzymes, enabling effective diagnostic and therapeutic functions.
This approach may lead to advances in noninvasive glucose monitoring and enhanced tissue regeneration for diabetic patients.

Abstract

The dual challenge of continuous glucose monitoring and treating chronic, infected wounds in diabetes demands innovative materials with integrated diagnostic and therapeutic capabilities. Herein, engineered through biomimetic coencapsulation of glucose oxidase (GOx) and a bimetallic metal–organic framework (MOF), MOF-919 within ZIF-8, this study reports a programmable nanozyme composite─GMZ. MOF-919's spatially resolved Fe/Cu active sites enable microenvironment-adaptive catalysis: Fe nodes drive peroxidase (POD)-like •OH generation for antibacterial action, while Cu centers switch to antioxidant superoxide dismutase (SOD)/catalase (CAT)-like functions at physiological pH, with density functional theory (DFT) calculations confirming Fe-mediated electronic optimization reduces ROS-scavenging energy barriers. The ZIF-8 matrix enhances GOx stability and confinement-accelerated cascade kinetics, enabling a wearable sweat glucose patch and a nanofiber dressing that eradicates bacteria via glucose oxidation producing H2O2 and resolves oxidative stress to remodel chronic wounds. This work presents a singular nanozyme platform that seamlessly bridges noninvasive biosensing and intelligent tissue regeneration, offering a powerful and unified strategy for the comprehensive management of diabetes.

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