September 27, 2025

CYP2D6 genotyping in a Korean cohort: comparative analysis with Asian, Caucasian, and African populations

Key Points

CYP2D6 genotyping shows significant genetic variability which influences drug metabolism among populations.
Allele distributions in the Korean cohort indicate notable differences compared to Asian, Caucasian, and African groups.
The study involved comprehensive comparative analysis to address the limited data on Korean CYP2D6 distributions.
Understanding CYP2D6 variability can optimize drug therapy, with implications for personalized medicine.

Abstract

Background Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic enzyme responsible for metabolizing approximately 20% of commonly prescribed drugs. Its genetic variability contributes to interindividual and interethnic differences in drug response. However, large-scale studies on CYP2D6 allele distributions in the Korean population remain limited.

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