Respiratory system is the system of gaseous exchange. If any part of the system affected then the respiratory diseases occur like asthma, COPD, bronchitis etc. for treating such respiratory diseases salbutamol sulphate was used. Salbutamol sulphate as a model β2 adrenergic agonist drug which under goes first pass metabolism in liver, which can decrease the bioavailability of drug. Thus, the aim of this study was to improve bioavailability, swift action and improved patient compliances. This work represents a new design of salbutamol sulphate Orodispersible tablets using box-Behnken design with the three independent variables: the two super disintegrants (jackfruit seed starch and Lepidium sativum seed mucilage) and a binder (polyvinyl pyrrolidone K-30) were selected to study their effect on the critical dependent variables. The natural ingredients are extracted and desirable evaluated. All the evaluation pre-compressional and post-compressional was observed. The responses variables were analysed and the optimised formulation was obtained using the box-Behnken design.
Yadav et al. (Fri,) studied this question.