Aim: With the advent of the internet, patients are increasingly turning to online resources and AI-powered chatbots for answers to their questions, particularly regarding endodontic treatment. The aim of this study is to compare three large language models (LLMs) (ChatGPT-5, Gemini 2.5 Flash, and DeepSeek-V3.1) in terms of accuracy, understandability, and readability, based on the answers provided to frequently asked endodontic questions. Methodology: Thirty open-ended frequently asked questions were generated from selected topics using the AlsoAsked and AnswerThePublic websites. The questions were administered on September 2, 2025, in separate reset sessions for each model, with a single response allowed. Two experienced endodontists independently and in a double-blind manner scored the accuracy of the responses using a 5-point Likert scale. The understandability of the responses was analyzed using the Patient Education Materials Assessment Tool for Printed Materials (PEMAT-P) tool. Readability was assessed using the Flesch-Kincaid Readability Score (FRES), Flesch-Kincaid Grade Level (FKGL), Gunning Fog Index (GFI), Simple Measure of Gobbledygook (SMOG), and Coleman-Liau Index (CLI) indexes. Inter-rater reliability was assessed using ICC, and group comparisons were performed using ANOVA/Kruskal-Wallis tests based on normality, followed by post-hoc Dunn-Bonferroni tests. Results: Inter-rater agreement was excellent (accuracy ICC: 0.908–0.917; reliability ICC: 0.992–0.995; all p0.05). The understandability (PEMAT-P) scores were similar (p=0.683), and all models scored above 70% (ChatGPT-5, 77.46%; Gemini, 76.04%; DeepSeek-V3.1, 77.57%). Differences were found in readability metrics: DeepSeek-V3.1 scored higher than ChatGPT-5 in FRES (p=0.044); Gemini scored higher than DeepSeek-V3.1 in FKGL (p=0.001); In GFI, Gemini 2.5 Flash scored higher than both ChatGPT-5 (p=0.036) and DeepSeek-V3.1 (p0.05). Conclusions: For patient questions related to endodontics, DeepSeek-V3.1 outperformed ChatGPT-5 and Gemini 2.5 Flash in terms of accuracy. While all models produced similar scores above the PEMAT-P understandability threshold (70%), there were significant differences in readability metrics; furthermore, no model consistently reached the recommended 6th–8th grade level. LLMs can support patient education and communication; however, dentist oversight is required regarding the clinical accuracy and individual suitability of responses, and chatbots should not be used as the sole decision-makers. How to cite this article: Taşyürek M, Adıgüzel Ö, Gündoğar M, Goncharuk-Khomyn M, Ortaç H. Comparative evaluation of the responses from ChatGPT-5, Gemini 2.5 Flash, and DeepSeek-V3.1 chatbots to patient inquiries about endodontic treatment in terms of accuracy, understandability, and readability. Int Dent Res. 2025;15(Advanced Online). doi:10.5577/indentres.662
Taşyürek et al. (Sun,) studied this question.