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September 30, 2025Open Access

Sarcopenia as a prognostic marker in patients undergoing pancreaticoduodenectomy: an updated meta-analysis

JHJie HeChengdu Medical College JLJia LiHebei Medical University JLJia LiuNanjing University of Science and Technology

Key Points

Patients with sarcopenia face a significantly increased risk of major complications after pancreaticoduodenectomy, including mortality.
The meta-analysis of 30 articles reveals that the prevalence of sarcopenia in these patients is 35%, emphasizing its clinical relevance.
Significant associations exist between sarcopenia and both disease-free survival and overall survival in the postoperative setting.
These findings highlight the need for stricter definitions of sarcopenia in future studies to validate its prognostic implications.

Abstract

Background Sarcopenia is prevalent among patients undergoing pancreaticoduodenectomy (PD). However, the effect of sarcopenia on postoperative complications and the prognosis of patients undergoing PD remain controversial. This meta-analysis aimed to evaluate the potential use of sarcopenia as a prognostic indicator in patients undergoing PD. Methods A systematic search was conducted using the databases of Web of Science, EMBASE, China National Knowledge Infrastructure, Cochrane Library, and PubMed from inception to March 14, 2025, to identify studies on sarcopenia in patients undergoing PD. The pooled prevalence of sarcopenia and its 95% confidence interval (CI) were calculated, and heterogeneity was assessed using the I² test. Associations between sarcopenia and major postoperative complications, postoperative pancreatic fistula (POPF), postoperative biliary fistula (POBF), mortality, disease-free survival (DFS), and overall survival (OS) were expressed as odds ratios (ORs) or hazard ratios (HRs) with 95% CIs. Statistical analyses were performed using Stata version 11.0. Results This meta-analysis included 30 articles involving 5,323 participants. The prevalence of sarcopenia before PD was 35%. Patients with sarcopenia exhibited a significantly higher risk of major complications (Clavien–Dindo CD grade ≥ III) (OR = 1.84, 95% CI = 1.26–2.69, P = 0.002), POPF (OR = 1.47, 95% CI = 1.13–1.93, P = 0.004), and POBF (OR = 1.53, 95% CI = 1.05–2.25, P = 0.028) than those without sarcopenia. In addition, postoperative mortality was higher in patients with sarcopenia (OR = 3.52, 95% CI = 2.01–6.19, P = 0.002). Patients without sarcopenia exhibited better DFS and OS after PD than those with sarcopenia (DFS: HR = 2.28, 95% CI = 1.18–2.88, P 0.001; OS: HR = 3.15, 95% CI = 2.49–3.98, P 0.001). Conclusion A high proportion of patients presented with sarcopenia before undergoing PD. Patients undergoing PD with sarcopenia face a higher risk of overall incidence of major complications (CD grade ≥ III), POPF, POBF, and mortality, and they exhibit worse DFS and OS than those without sarcopenia. Future studies should adopt stricter definitions of sarcopenia to further validate these findings. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42025635939 , identifier CRD42025635939.

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