Antibiotic Susceptibility Trends Among Klebsiella Pneumoniae Isolates in Clinical Specimens at a Tertiary Care Hospital

Background: Klebsiella pneumoniae is a leading etiological agent in both community- and hospital-acquired infections, now complicated by increased antibiotic resistance. A retrospective study in the Department of Microbiology, M.P. Shah Methods: Government Medical College, included 600 non-repetitive K. pneumoniae isolates (December 2024–May 2025). Data from WHONET surveillance were analyzed using CLSI 2024 guidelines. Of 600 isolates, most originated from urine (35.8%) and pus (27.0%). Males represen Results: ted 53.1% of cases. Patients aged 51–70 years had the highest burden. Over 69% of isolates were resistant to third-generation cephalosporins. Carbapenem sensitivity exceeded 92%. High resistance rates to first-line antibiotics underscore the urgent need for robust antibiotic Conclusion: stewardship. Judicious use of carbapenems is recommended.