Prediction of Hyponatremia in Patients With Nasopharyngeal Cancer on Concurrent Chemoradiotherapy

Objective: Hyponatremia occurs in patients with nasopharyngeal cancer (NPC) on chemoradiotherapy and causes prolonged hospitalization, low quality of life, and increased mortality. This study aimed to determine the associated factors of hyponatremia in patients with NPC on chemoradiotherapy and investigate changes in hyponatremic events over time. Methods: We retrospectively reviewed patients with NPC who underwent complete concurrent chemoradiotherapy between 2014 and 2024. Hyponatremia was defined as serum sodium levels 50 years, tube feeding alone, advanced nodal metastasis, distant metastasis, carboplatin use, high-grade mucositis, and skin complications. Conclusions: Hyponatremia frequently occurs in the first 2 months of NPC treatment. Advanced age, tube feeding alone, advanced nodal metastasis, distant metastasis, carboplatin use, high-grade mucositis, and skin complications are significantly associated with hyponatremic events.