Supplementary Figure S1 from Spatial Tumor Immune Microenvironment as a Prognostic and Predictive Biomarker in Anti–EGFR-Based Maintenance for RAS wt Metastatic CRC—The PanaMa (AIO KRK0212) Trial

Key Points

• Cox Regression Analysis indicates a correlation between tumor immune microenvironment and survival outcomes in metastatic CRC.
• Epithelial tumor expression in the invasive margin significantly predicts overall and progression-free survival rates.
• Univariate analysis highlights the immune microenvironment's role as a potential prognostic biomarker in treatment response.
• The study aims to validate immune profiling's usefulness for guiding anti–EGFR therapy in metastatic CRC patients.