Supplementary Figure S6 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Key Points

• Enhancing antitumor immunity is observed by preventing aging stress-induced mitophagy, contributing to better outcomes.
• Key findings suggest that the amyloid-β precursor protein impacts fumarate levels, which are crucial for immune function.
• Methods employed include analyzing therapeutic approaches in a model with 3xTg T-cells against tumor growth and progression.
• This research may lead to novel therapies targeting aging stress to augment immune responses in cancer patients.