Supplementary Figure S6 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy | Synapse
October 2, 2025
Supplementary Figure S6 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
Key Points
Inhibiting nrf2 translation increased lymphoma cell sensitivity to ferroptosis.
Significant lipid peroxidation and ROS levels were observed post-intervention.
Bliss synergy plots support the efficacy of combining therapies in lymphoma treatment.
This approach highlights the potential for improved immunotherapy outcomes in lymphoma patients.
Abstract
Zotatifin sensitizes cells to ferroptosis; includes lipid peroxidation, ROS analysis, and Bliss synergy plots.