Supplementary Figure 14 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• Tumor-associated macrophages drive immunotherapy resistance by compromising CD8 T-cell function.
• CyTOF characterization of T cells reveals changes linked to resistance in clear-cell renal cell carcinoma.
• These findings highlight the role of tumor-associated macrophages in modulating T-cell responses.
• Understanding these interactions may assist in developing new therapeutic strategies for clear-cell renal cell carcinoma.

Abstract