Supplementary Figure 15 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• CD8+ T-cell dysfunction is linked to tumor-associated macrophages in clear-cell renal cell carcinoma, highlighting a key interaction.
• Characterization of CD8+ T cells using flow cytometry demonstrates the impact of tumor-associated macrophages on immunotherapy outcomes.
• The study employs flow cytometry to assess T-cell characteristics, providing critical insights into immunotherapy resistance mechanisms.
• This work underscores the potential of targeting tumor-associated macrophages to improve immunotherapy efficacy in renal cell carcinoma.

Abstract