Supplementary Figure 5 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• Increased spp1+ TAM infiltration correlates with resistance to immunotherapy in ccRCC patients, affecting treatment outcomes.
• The study reveals a significant association with objective response rate (ORR) among this population treated with immunotherapy.
• Using univariate logistic regression analysis, the correlation between TAM infiltration and treatment effectiveness was assessed.
• This finding highlights the role of TAMs in immunotherapy response, suggesting potential targets for enhancing treatment efficacy.

Abstract