Background: Chronic obstructive pulmonary disease represents a major health challenge worldwide, accounting for substantial illness and death. Episodes of acute deterioration accelerate the decline in respiratory capacity and are a leading cause of hospital admissions. Adequate vitamin D status is integral to immune regulation and pulmonary health, whereas deficiency has been consistently linked with heightened vulnerability to infections and more frequent disease flare-ups in individuals with chronic obstructive pulmonary disease. Objective: To determine the association of serum vitamin D concentrations in patients admitted with acute exacerbation of COPD. Design of the Study: Case-control study: Study duration and settings: The study was conducted in the Department of Pulmonology, Combined Military Hospital (CMH) Rawalakot, Azad Kashmir, from March to August 2024. Methodology: A total of 84 participants were included, comprising 42 patients aged 40 years and above with acute exacerbation of COPD and 42 healthy controls without chronic respiratory disease. Detailed clinical histories and physical examinations were conducted. Serum 25-hydroxy vitamin D concentrations were measured using chemiluminescence immunoassay. Study Results: In this study the mean serum vitamin D level in COPD patients was 26.32 ± 10.39 ng/mL, significantly lower than that of controls, which was 34.14 ± 11.09 ng/mL (p = 0.001). Vitamin D deficiency was more frequent among COPD patients (35.7%) compared with controls (14.3%). Conclusion: In this study COPD exhibited markedly reduced serum vitamin D concentrations in comparison with healthy control subjects.
Baig et al. (Fri,) studied this question.