What type of study is this?

This is a Experimental Study study.

October 5, 2025

Development and validation of UV spectroscopic method for the estimation of Linagliptin in its pure form and pharmaceutical dosage form

Key Points

The developed UV spectroscopy method accurately estimates linagliptin levels in pharmaceutical dosage forms.
It shows a linearity range of 1-50 µg/mL with an impressive R2 value of 0.9999.
The method achieves low limits of detection and quantification at 0.05657 and 0.1714 µg/mL.
No significant interference from excipients indicates robustness for pharmaceutical applications.

Abstract

The purpose of this study was to develop a reliable, rapid and sensitive method based on Ultra Violet spectroscopy (UV) for the determination of an anti-diabetic drug Linagliptin (LIN) in its pure form as well as in its pharmaceutical dosage forms. Different solvent blends were screened to select solvent blend which suits for the study. The solvent blend selected was comprising of Acetonitrile: Methanol: DW at 1:1:1 and same was used for the development, validation and quantification of LIN. The results show the linearity in the concentration range (1-50 µg/mL) with correlation coefficient R2 = 0.9999 with percent recovery (100 – 100.3 %) with RSD was less than 2%, LOD and LOQ 0.05657, 0.1714 µg/mL respectively. This method can show high quality and there is no significant interference with the excipients and in pharmaceutical forms. None of the studies showed the development of this method before.

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