Introduction: Giant cell tumor of the tendon sheath (GCTTS) is a benign, slow-growing soft tissue neoplasm that typically arises from the synovial lining of tendon sheaths in the hand and digits. It is the second most common soft tissue tumor of the hand after ganglion cysts. While benign, GCTTS is locally aggressive and has a documented recurrence rate of up to 45%. Materials and Methods: We present a case series of 8 patients diagnosed with GCTTS involving flexor and extensor tendons of the hand. All patients underwent thorough clinical evaluation and magnetic resonance imaging (MRI), assessment before complete surgical excision. Histopathological confirmation was obtained in each case. Results: There was a female preponderance with 5 patients being females. The mean age of patients was 30.8 years. At a mean follow-up of 55 months (range: 48–62 months), recurrence was observed in one case. Conclusion: GCTTS should be considered in the differential diagnosis of digital swellings. MRI is essential for surgical planning, and complete resection with preservation of critical structures minimizes the risk of recurrence. A multidisciplinary approach combining imaging, surgery, and pathology ensures optimal patient outcomes. Keywords: Giant cell tumor, tendon sheath, flexor tendon, hand tumor, magnetic resonance imaging, recurrence, histopathology.
Parakh et al. (Wed,) studied this question.
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