Structural Insights into the Activity of Carbapenemases: Understanding the Mechanism of Action of Current Inhibitors and Informing the Design of New Carbapenem Adjuvants

Key Points

• The study reveals structural insights into carbapenemases, clarifying their mechanisms and challenges in treatment.
• Current inhibitors, such as β-lactamase inhibitors, show limited effectiveness against resistant strains of bacteria.
• Understanding the action of serine and metallo-β-lactamases is crucial for designing more effective carbapenem adjuvants.
• Potential for developing new inhibitors highlights the ongoing necessity to combat antimicrobial resistance effectively.

Abstract