Benzyne formations and reactions with amines under solvent-free conditions in a mixer mill

Key Points

• Benzyne formation occurs under solvent-free conditions, enabling efficient reactions with amines.
• Treatment of Kobayashi's o-trimethylsilylphenyl triflate with TBAF results in the generation of benzyne.
• The mechanochemical approach offers a greener synthesis alternative, reducing solvent usage.
• The study shows practical applications in producing N-phenylated products via amine reactions.