Remission of T2DM has been shown to be possible with dietary modifications and significant weight loss in clinical trials as well as real-world studies (1,2) . Low-Carbohydrate Diets (LCDs; 0.05). At 6-months, all participants had HbA1c ≤ 48mmol/mol, indicating maintenance of remission. No statistically significant changes were observed in blood lipids except for HDL-C, which improved from baseline to 6 months (+0.17 mmol/L 95% CI, -0.31 to -0.02, p=0.019). A statistically significant weight loss was observed between baseline and 3- months (-3.6 kg 95% CI, 0.5 to 6.6, p=0.02) and baseline and 6-months (-3.7 kg 95% CI, 0.3 to 7.1, p=0.03). There were no significant changes in carbohydrate intake over time. However, two participants’ carbohydrate intake exceeded 130 g per day at both baseline and 3-months while 3 participants exceed 130 g at 6 months, indicating a trend of increasing carbohydrate intake with time. While energy intake did not change significantly, it was reported to fall below the DRVs according to sex and age group. At all timepoints, fibre intake was found to be below the recommended 30 g per day. This study showed that people with newly induced T2DM remission can maintain it over 6 months in a real-world setting, with observed metabolic improvements. Adherence to a LCD was also shown to be possible, although a consistent low fibre intake was observed. Therefore, supporting people in achieving and maintaining T2DM remission through a well-planned diet within primary care could bring about significant benefits if scaled to a population level.
Aksoy et al. (Fri,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: