Invasive and non-invasive techniques aim to accelerate orthodontic tooth movement (OTM). Platelet concentrates like leukocyte platelet-rich fibrin (L-PRF), injectable platelet-rich fibrin (i-PRF), and platelet-rich plasma (PRP) are conservative techniques that show promise in bone preservation and healing, but there is conflicting evidence regarding their ability to speed OTM. Until January 2025, a thorough search was conducted using PubMed, LILACS, Web of Science, Scopus, Google, and Open Gray literature. Predetermined MeSH phrases and keywords were used to screen the studies. Randomized controlled trials (RCTs), assessing L-PRF in OTM, were the main emphasis of the inclusion criteria. Two reviewers independently screened and extracted the data, while a third arbitrated any disputes. Risk of bias (RoB) 2 was used to evaluate the RoB. Weighted mean differences (WMD), CIs, I 2 for heterogeneity, and funnel plots for publication bias were all employed in the meta-analysis. Six RCTs out of the 515 studies identified met the inclusion criteria. Three studies had some concerns, two had little risk, and one had a high RoB. The control group outperformed L-PRF in the meta-analysis (MD: 0.15, CI: 0.08–0.22). Although there is not much proof that L-PRF can speed up OTM, it does help with tissue recovery. Standardizing preparation, evaluating patient outcomes, and assessing long-term impacts should be integral to future studies. To ascertain its decisive significance in orthodontics, well-designed clinical studies are required.
Ramesh et al. (Thu,) studied this question.
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