A sustainable approach to the synthesis of 2-arylimidazo1,2-apyridines followed by sequential amino and bromo functionalization

Key Points

• The developed protocol enables efficient synthesis of 2-arylimidazo[1,2-a]pyridines, enhancing sustainability in chemical processes.
• Using carbon tetrabromide for the first time, this method achieves functionalization under solvent-free conditions while maintaining high yield.
• This methodology offers a practical approach, reducing environmental impact and improving accessibility to 2-arylimidazo derivatives.
• The results indicate a novel strategy for functionalization that could lead to wider applications in medicinal chemistry and materials science.

Abstract