Targeting the PHD2/HIF-1α/HO-1 pathway: A key role of trimetazidine in hypertensive nephropathy

Key Points

• Trimetazidine significantly improves kidney function in mice with hypertensive nephropathy, enhancing overall health.
• The study shows that trimetazidine effectively modulates the PHD2/HIF-1α/HO-1 pathway in kidney tissues.
• This analysis used mice to explore the mechanisms by which trimetazidine affects hypertensive nephropathy.
• These findings highlight trimetazidine's potential as a therapeutic agent for managing hypertensive nephropathy.

Abstract