Zinc oxide nanoparticles (ZnO NPs) are widely utilized in various industrial and biomedical applications due to their unique physicochemical properties. However, increasing evidence suggests that excessive exposure to ZnO NPs can lead to significant toxicity in vital organs, including the liver, kidneys, spleen, and heart, primarily through oxidative stress, inflammation, and cellular damage. This study investigates the protective potential of ginger (Zingiber officinale) against ZnO NP induced toxicity in these organs. Adult rats were divided into control, ZnO NP treated, ginger-treated, and ZnO NP plus ginger-treated groups. Biochemical parameters, histopathological examinations, and oxidative stress markers were analyzed to assess organ function and tissue integrity. Results demonstrated that. ZnO NP exposure significantly altered liver, kidney, and spleen function markers. Co-administration of ginger ameliorated these effects, restoring biochemical parameters and preserving histological architecture, likely due to its potent antioxidant and anti-inflammatory properties. These findings suggest that ginger may serve as a natural therapeutic agent to mitigate the toxic effects of ZnO NPs on vital organs.
Sharif et al. (Wed,) studied this question.