Placental transcriptomic profiling showed disturbance of chemokine activities and lymphocyte chemotaxis in pregnancy with fetal growth restriction

Key Points

• Altered chemokine activities and lymphocyte chemotaxis were identified in placentas from pregnancies with fetal growth restriction.
• The transcriptomic profiling study revealed significant disturbances associated with placental dysfunction in FGR cases.
• Observational analysis identified key transcriptomic features linked to perinatal death and adverse pregnancy outcomes related to FGR.
• These findings highlight the importance of understanding placental mechanisms to address complications arising from fetal growth restriction.