Yersinia ruckeri YRB periplasmic binding protein YiuA selectively recognizes a Fe(iii)-mono-catecholate siderophore

Key Points

• YiuA exhibits unprecedented selectivity for the Fe(iii) complex of the mono-catechol siderophore.
• The study highlights the binding affinity of YiuA for the Fe(iii)–(Rb MC)2 complex over ruckerbactin.
• The findings indicate intricate molecular mechanisms governing iron acquisition in Yersinia ruckeri.
• Understanding YiuA's selectivity could inform approaches to target iron uptake in pathogens.