In Ayurveda, Ama is considered the root cause of many diseases. Ama contributes significantly to the onset and progression of the disease. Ama is derived from Am Dhatu Nich pratyaya. Ama is the substance which remains uncooked, immature and undigested. The formation of ama depends on various factors, including physical and mental factors, as described in the vitiation of Agni. This denotes impaired metabolism,which leads to the accumulation of toxins. Thesecannot beneutralized and areeasily eliminated by the body. When toxins accumulate in body tissues and skin,they can lead toskin diseases such asVicharchika, Mukhadushika, Switra, and Kitibhakushta, as well as autoimmune conditions like systemic lupus erythematosus (SLE) and scleroderma.
Agna et al. (Tue,) studied this question.