The coMOLLI method for myocardial T1 mapping at 5T demonstrated high accuracy in phantom studies with relative errors within 5% and feasibility in vivo across 21 healthy volunteers and 9 patients.
Does the coMOLLI method provide accurate myocardial T1 mapping at 5T MRI in phantoms and human subjects?
The coMOLLI method demonstrates high accuracy and feasibility for myocardial T1 mapping at 5T MRI, showing potential for clinical cardiac imaging.
BACKGROUND: Accurate myocardial T1 mapping at 5T remains a technical challenge due to field inhomogeneity and prolonged T1 values. The aim of this study was to develop an accurate and clinically applicable myocardial T1 mapping technique for 5T magnetic resonance imaging systems and validate its performance in a multicenter study. METHODS: variations over the heart at 5T, using adiabatic hyperbolic secant and tangent/hyperbolic tangent (Tan/Tanh) pulses. The method was validated in phantom experiments, as well as in 21 healthy volunteers and 9 patients. RESULTS: = 8 ms. In phantom studies, coMOLLI showed high accuracy versus reference inversion recovery-fast spin echo, yielding relative errors within 5% for all nine vials. In in vivo studies, the average native myocardial T1 values across 21 healthy volunteers were 1468 ± 48 ms, 1514 ± 39 ms, and 1545 ± 50 ms, and blood T1 values were 2182 ± 132 ms, 2124 ± 153 ms, and 2131 ± 158 ms for apical, middle, and base slices, respectively. CONCLUSION: The coMOLLI method demonstrated high accuracy in phantom studies and feasibility in vivo studies. By adopting the widely used 5-(3)-3 MOLLI acquisition scheme, it shows potential for clinical cardiac imaging at 5T.
Ge et al. (Thu,) conducted a other in Myocardial T1 mapping (n=30). coMOLLI method vs. reference inversion recovery-fast spin echo was evaluated on Accuracy of T1 mapping. The coMOLLI method for myocardial T1 mapping at 5T demonstrated high accuracy in phantom studies with relative errors within 5% and feasibility in vivo across 21 healthy volunteers and 9 patients.