Abstract: Herbal medicine turns up as a significant therapeutic alternative for many disorders. But its poor bioavailability might limit its use in clinical applications. The utilization of phytosome technology has been found to significantly improve the bioavailability of numerous wellknown nutraceuticals and herbal extracts such as milk thistle, ginkgo biloba, grape seed, green tea, hawthorn, ginseng, turmeric, centella, ammi, and more. Phytosomes improve the ability of hydrophilic phytoactive compounds to pass through cell membranes and enhance the solubility of lipophilic polyphenols in water-based environments. As a result of phytoosomes have enhanced pharmacokinetics and pharmacological effects andare an effective method for treating various disorders. Additionally, phytosome technology has broadened opportunities in fields such as liver wellbeing, weight control, and managing inflammatory ailments. Its capacity to enhance the transport of particular plant constituents to specific bodily tissues makes it a cutting- edge fresh possibility for natural solutions in these realms. In conclusion, phytosomes maintain their importance by enhancing the effectiveness of nutraceuticals, phytoconstituents and botanical supplements and holding promise for enhancing diverse aspects of health and well-being. However, challenges such as complex chemical structures hindering large-scale synthesis, variability in phytoconstituent content affecting consistency, and the absence of standardized regulatory pathways for hybrid nutraceutical-drug products complicate clinical translation. Additionally, the limited number of large-scale, randomized controlled trials restricts the generalizability of findings and regulatory approval processes. To fully realize the potential of phytosome technology, future research should focus on rigorous pharmacokinetic standardization, adoption of Quality by Design (QbD) strategies, and validation through welldesigned clinical trials. Integrating artificial intelligence and advanced analytical techniques can further optimize formulation processes and ensure consistent quality. Addressing these challenges will enable phytosomes to play a pivotal role in modern therapeutics and integrative medicine, offering enhanced efficacy and safety profiles for plant-based interventions. It serves as a link and fuses the benefits of both traditional and advanced drug delivery technologies.
Kamini et al. (Wed,) studied this question.