A Numerical Comparison of Magnetic Nanoparticle Hyperthermia in Breast, Muscle, and Prostate Tumors.

This study aims to compare the efficacy of magnetic nanoparticle hyperthermia for treating cancerous tissues in two distinct scenarios: breast and muscle/prostate tumors. Heat transfer dynamics during magnetic hyperthermia cancer therapy are explored using intravenously administered nanoparticles to a muscle/prostate tumor and intratumoral injection into a breast tumor. Utilizing non-Newtonian blood rheological models, we analyze a complex geometric domain for both tumor types and apply the mixed finite element technique for solving the governing equations. The impact of varying magnetic field frequencies and injected nanoparticle concentrations on heat transfer and nanoparticle transport within muscle/prostate, and breast tissues are examined numerically. Higher magnetic field frequencies and injected nanoparticle concentrations were found to increase localized heating in tumor regions, reduce therapy duration, and maximize thermal damage to cancer cells for both tumor configurations. This research provides valuable insights for optimizing magnetic hyperthermia parameters for different tumor types and also highlights the potential for personalized treatment strategies.