TiO2 Nanotube-Enabled Glucose Biosensing: Transformative Insights from 2009 to 2024

The global rise in diabetes has intensified the demand for advanced glucose monitoring technologies that provide continuous, accurate, and real-time detection. Traditional sensing approaches often face challenges related to sensitivity, long-term stability, and suitability for wearable or implantable systems. In this context, titanium dioxide (TiO2) nanotube arrays (NTAs) have emerged as a versatile platform owing to their well-defined nanostructure, tunable surface properties, and semiconductor nature, which collectively enable enhanced performance across different sensing modes. These include enzymatic systems, non-enzymatic configurations, and photoelectrochemical (PEC) sensors. While each sensing strategy offers considerable potential, certain inherent limitations continue to be explored. Ongoing research is gradually uncovering various pathways to enhance performance and reliability through the introduction of novel materials and system designs. Looking forward, the broader integration of TiO2-based sensing platforms with evolving technological frameworks may contribute to the advancement of more adaptive and user-friendly glucose monitoring solutions.