The free-breathing multimap sequence reduced total scan time compared to conventional methods (66 vs 195 s; p<0.001) and achieved a higher AUC (0.904 vs 0.801) for detecting LGE-positive patients.
Observational (n=109)
Does a free-breathing multimap sequence improve diagnostic performance and reduce scan time compared to conventional mapping sequences for myocardial fibrosis detection in non-ischemic cardiomyopathy?
A novel free-breathing multimap sequence significantly reduces cardiac MRI scan time and improves diagnostic performance for detecting myocardial fibrosis in non-ischemic cardiomyopathy compared to conventional mapping.
Absolute Event Rate: 66% vs 195%
p-value: p=<0.001
BACKGROUND: Quantitative myocardial mapping is critical for tissue characterization in non-ischemic cardiomyopathy (NICM). However, conventional techniques require separate breath-hold acquisitions, prolonging scan time and impairing co-registration. This study aimed to assess the feasibility and diagnostic performance of a novel free-breathing multimap (FBmultimap) sequence enabling simultaneous T1, T2, and T1ρ mapping in a single acquisition. METHODS: Onehundred-nine participants were prospectively enrolled, including 48 with hypertrophic cardiomyopathy (HCM), 28 with dilated cardiomyopathy (DCM), and 33 healthy controls. All underwent cardiac MRI with both FBmultimap and conventional mapping sequences (modified Look-Locker inversion recovery (MOLLI) T1, T2-prepared balanced steady-state free precession (bSSFP), and T1ρ-prepared bSSFP). Image quality was assessed using subjective (four-point Likert scale) and objective (edge sharpness) methods. Myocardial relaxation times were analyzed in the following two subgroups: (1) HCM and DCM vs. controls, and (2) late gadolinium enhancement (LGE)-positive and LGE-negative patients vs. controls. Combined diagnostic indices (T1 + T1ρ) were derived using logistic regression. Diagnostic performance was evaluated using receiver operating characteristic analysis across the following six models: FBmultimap (T1 + T1ρ), FBmultimap T1, FBmultimap T1ρ, conventional (T1 + T1ρ), MOLLI T1, and T1ρ-prepared bSSFP, with area under the curve (AUC) calculated. RESULTS: FBmultimap significantly reduced total scan time for T1 + T2 + T1ρ mapping to 66±6 s, compared with 195±10 s using conventional methods (p0.05). T1 and T1ρ values measured by FBmultimap were significantly elevated in HCM and DCM groups compared to controls, regardless of LGE status (all p<0.05), whereas T2 values showed no significant differences. FBmultimap (T1 + T1ρ) achieved higher AUCs for distinguishing LGE-positive (0.904) and LGE-negative (0.859) patients from controls than FBmultimap T1 (0.877 and 0.829), FBmultimap T1ρ (0.608 and 0.764), MOLLI T1 (0.770 and 0.671), T1ρ-prepared bSSFP (0.734 and 0.778), and the conventional (T1 + T1ρ) model (0.801 and 0.819). CONCLUSION: FBmultimap enables rapid, co-registered, free-breathing mapping of myocardial T1, T2, and T1ρ with high reproducibility and improved diagnostic performance over conventional single-parameter methods. It holds promise as a clinically applicable tool for myocardial fibrosis detection, risk stratification, and longitudinal monitoring in patients with HCM and DCM.
Wu et al. (Wed,) conducted a observational in Non-ischemic cardiomyopathy (n=109). Free-breathing multimap (FBmultimap) sequence vs. Conventional mapping sequences (MOLLI T1, T2-prepared bSSFP, and T1ρ-prepared bSSFP) was evaluated on Total scan time for T1 + T2 + T1ρ mapping (p=<0.001). The free-breathing multimap sequence reduced total scan time compared to conventional methods (66 vs 195 s; p<0.001) and achieved a higher AUC (0.904 vs 0.801) for detecting LGE-positive patients.