A 63-year-old female with chronic atrial fibrillation presented with shortness of breath for 1 month, illustrating a case of amiodarone pulmonary toxicity.
Case Report (n=1)
Highlights a case of amiodarone pulmonary toxicity in a patient with chronic atrial fibrillation, emphasizing the need for clinical suspicion and exclusion of other causes.
Case RepoRthigh-dose supplemental oxygen, and pulmonary angiography. 4he possible mechanisms postulated are cytotoxic T cell-mediated, direct toxicity to the lung, and indirect immunological reaction, especially in genetically susceptible individuals. 2Amiodarone is metabolized by CYP3A4 to desethyl-amiodarone, which accumulates in the lungs more than amiodarone itself, causing direct toxicity to lung parenchyma. 2 In the lungs, it accumulates mainly in type 2 pneumocytes and alveolar cells.Hence, there is no role in checking serum amiodarone levels for the diagnosis.Diagnosis is mainly by excluding all other possible causes. 2,3he prevalence of amiodarone toxicity is 1-5%. 2,5Prognosis depends on the form of pulmonary involvement.Interstitial pneumonitis usually has a favorable prognosis and responds well to systemic corticosteroids.But it takes weeks to months for the resolution of symptoms as well as chest findings, as the drug elimination time is longer. 3Reported mortality associated with pulmonary involvement is around 10%. 3 Case RepoRtA 63-year-old female with a known case of chronic atrial fibrillation (AF) came with complaints of shortness of breath for 1 month, which has been exacerbated for the last 15 days with modified Medical Research Council (mMRC) grade 2. The patient also has
Ravikeerthy et al. (Thu,) conducted a case report in Amiodarone Pulmonary Toxicity (n=1). Amiodarone was evaluated. A 63-year-old female with chronic atrial fibrillation presented with shortness of breath for 1 month, illustrating a case of amiodarone pulmonary toxicity.
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