Abstract Background A dysregulated systemic inflammatory response to infection causes sepsis, a leading cause of death and illness globally. Sepsis patients at high risk of poor outcomes must be identified early for timely and sufficient care. Objective Assessment of the predictive value of the platelets to lymphocytes ratio obtained from the blood sample taken the day of ICU admission for the purpose of determining the severity of sepsis. Patients and Methods A total of 70 patients with were subjected to selective investigations included complete blood count and arterial blood gases. As regard mortality distribution cases were divided into survivors (40 cases) and non survivor (30cases). Primary outcome was hospital mortality rate and secondary outcome measures were mean arterial blood pressure, temperature, heart rate, total leuococytic count and serum lactate. Results There was statistically significant lower mean value of platelets to lymphocytes ratio in non-survivor group comparing to survivor group. ROC curve analysis proved good discriminating power of the platletes to lymphocytes ratio between non-survival and survival where accuracy 85.7% at cutoff point ! 96.7 with sensitivity 90% and specificity82.5%. There was a statistically significant higher mean value of WBC (t/ccm) and serum lactate (mmol/L) in non-survivor group compared to survivor group. Conclusion PLR is a potential biomarker that is easily incorporated into clinical settings to help predict and prevent the death from sepsis.
A Sat, study studied this question.