Coccinia grandis (ivy gourd) leaves are widely utilized in traditional medicine across South and Southeast Asia yet remain underexplored from a comprehensive scientific perspective. This study addresses this knowledge gap by systematically examining their nutritional composition, phytochemical spectrum, and pharmacological attributes. Nutritional analyses revealed a high fiber content, moderate protein and lipid levels, and appreciable concentrations of essential minerals (e.g., calcium, magnesium, potassium, and iron). Phytochemical analysis confirmed the presence of multiple classes of bioactive compounds, including terpenoids, alkaloids, and flavonoids. Among the extracts, the n‐butanol fraction exhibited the highest phenolic content and potent antioxidant capacity, while the hydromethanol fraction demonstrated significant cytotoxic and antibacterial activities, as well as comparable anti‐inflammatory efficacy to diclofenac sodium. Collectively, these findings underscore the potential of C. grandis leaves as a promising source of bioactive compounds for nutraceutical and pharmaceutical applications targeting oxidative stress, microbial infections, and inflammatory disorders.
Akter et al. (Wed,) studied this question.