Association of Helicobacter pylori with Gallbladder, Pancreatic, and Colorectal Malignancies: A Prospective Observational Study

Abstract Background: Helicobacter pylori is a globally prevalent pathogen implicated in multiple gastrointestinal malignancies. While its role in gastric cancer is well established, its association with extragastric malignancies such as gallbladder carcinoma (GBC), pancreatic carcinoma (PC), and colorectal carcinoma (CRC) remains contentious. Objective: To evaluate the prevalence of H. pylori in gallbladder, pancreatic, and colorectal malignancies and to assess its potential associations. Materials and Methods: This prospective observational study was conducted between January 2023 and March 2025 at a tertiary hospital in India. Seventy-six histologically confirmed cases of GBC ( n = 42), CRC ( n = 24), and PC ( n = 10) underwent immunohistochemistry testing for H. pylori . The data were analyzed using SPSS v26.0; P 0.05). Conclusion: Although H. pylori was detected in a subset of GBC, PC, and CRC cases, the association was not statistically significant. Further multicenter studies with larger cohorts are necessary to explore potential etiological roles.