ABSTRACT Background and Aims The recent emergence and rapid spread of monkeypox (Mpox) have become a global public health concern. Gaps in proper information dissemination can cause confusion and knowledge divergence among the general public, leading to difficulties in disease management. Therefore, this study aimed to assess the overall knowledge, attitude, and practice (KAP) regarding Mpox among the general population of Bangladesh to help implement optimal public health interventions. Methods A cross‐sectional study was conducted using an online questionnaire survey to evaluate the KAP related to Mpox among the general population of Bangladesh. A total of 1025 KAP domains were registered during the survey, among which 938 were eligible for final analysis. Comparisons between different groups were performed using the Wilcoxon signed‐rank and the Kruskal–Wallis test. Additionally, a multivariable logistic regression analysis was conducted to identify factors associated with williness to practice preventive behaviours against Mpox. Results Only 7.25% (68/938) of participants demonstrated good knowledge, 20.58% (193/938) had positive attitudes, and 25.05% (235/938) were willing to practice preventive measures toward Mpox prevention, indicating overall inadequate KAP levels. The Kruskal–Wallis test revealed statistically significant differences in knowledge scores based on education level ( p value = 0.004), age group ( p value = 0.008), and division ( p value = 0.009). Similarly, significant variations in attitude scores were observed across areas of residence ( p value = 0.003), education level ( p value < 0.001), and age group ( p value = 0.002). Furthermore, both univariate and multivariable logistic regression analyses identified gender, knowledge level, and attitude score as significant predictors of willingness to engage in preventive practices. Conclusion The low KAP scores suggest an urgent need for mass awareness campaigns for Mpox prevention in Bangladesh. The findings of this study could assist policymakers in taking necessary steps to mitigate the potential public health burden associated with Mpox in the country.
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