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Introduction: The Microsponge Drug Delivery System (MDDS) is a biocompatible platform for targeted delivery of poorly soluble or unstable drugs via various routes. This review highlights the composition, preparation methods, applications, and future prospects of this delivery system. Methods: This review is based on a comprehensive literature survey examining the development and applications of the MDDS. Data were gathered from books, scientific reports, peer-reviewed articles, review papers, and patent databases. Relevant information was critically analyzed and synthesized to assess current progress and emerging trends in MDDS. Results: The literature reveals significant progress in MDDS, with suspension polymerization and emulsion solvent diffusion as key methods. Microsponges efficiently encapsulate various drugs, offering improved stability and controlled release. Growing patents and products reflect rising interest and development in this field. Discussion: MDDS offers advantages over conventional systems, including improved stability, controlled release, fewer side effects, and better patient compliance. Microsponges outperform microspheres and liposomes in entrapment efficiency, strength, and drug loading. Challenges, such as scalability and limited clinical application, remain; however, advances in polymer science and nanotechnology may help overcome these issues. Growing patents and research support their potential in personalized and targeted therapies. Conclusion: This review outlines the key aspects of MDDS, including its formulation, benefits, limitations, applications, and recent advancements. MDDS offers promising improvements in drug stability, targeting, and efficacy over conventional systems. However, wider clinical use depends on overcoming challenges like scalability, regulation, and safety. Continued innovation could establish microsponges as a vital tool in future drug delivery.
Burman et al. (Mon,) studied this question.