November 29, 2025Open Access
Mechanical Thrombectomy Reduces Increased High Sensitivity Troponin Levels in Intermediate-High Risk Pulmonary Embolism
Key Result
Mechanical thrombectomy using the FlowTriever device in intermediate-high or high risk pulmonary embolism was associated with immediate reductions in high-sensitivity troponin, lactate, and pulmonary arterial pressure.
Study Design
Type
Observational (n=32)
Structured PICO
Does mechanical thrombectomy improve periprocedural biomarkers and hemodynamics in patients with intermediate-high or high risk symptomatic pulmonary embolism?
P
Population
32 patients with symptomatic pulmonary embolism confirmed by computed tomography pulmonary angiography and classified as intermediate-high or high risk according to the current European Society of Cardiology guidelines.
I
Intervention
Mechanical thrombectomy using the FlowTriever device
O
Outcome
Periprocedural changes in troponin, lactate, pulmonary artery pressures, and vital signssurrogate
Mechanical thrombectomy in intermediate-high or high-risk pulmonary embolism is associated with immediate improvements in hemodynamics and reductions in myocardial and systemic biomarkers.
Abstract
BACKGROUND: Pulmonary embolism is associated with significant mortality and remarkably often subject to misdiagnosis, which further adversely affects prognosis. Disease severity and corresponding prognosis are strongly dependent on the risk constellation and determine the therapy. Therefore, we sought to analyse how mechanical thrombectomy influences short term clinical, laboratory, and haemodynamic findings in patients with symptomatic pulmonary artery embolism. METHOD: In this study, we retrospectively analysed clinical, laboratory, and haemodynamic parameters in 32 patients with symptomatic pulmonary embolism who underwent mechanical thrombectomy using the FlowTriever device. Only patients with pulmonary embolism confirmed by computed tomography pulmonary angiography and classified as intermediate-high or high risk according to the current European Society of Cardiology guidelines were included. The main outcome measures were periprocedural changes in troponin, lactate, pulmonary artery pressures, and vital signs. RESULTS: Reductions of increased heart rate, pulmonary arterial pressure, and right ventricle-to-left ventricle ratio were observed immediately after the procedure and in early clinical follow-up, as well as improvement in arterial oxygen saturation and demand. Interventional thrombectomy further resulted in a reduction of increased levels of high-sensitivity troponin and lactate. In summary, the analysis of this study shows consistent respiratory and haemodynamic improvements in line with other published data on mechanical thrombectomy with this device. CONCLUSIONS: Mechanical thrombectomy in patients with pulmonary artery embolism at intermediate-high risk was associated with an immediate and significant decrease in both specific myocardial and systemic biomarkers, for which prognostic relevance has been repeatedly demonstrated.