ABSTRACT Living systems achieve adaptability, motion, and self‐regulation through chemical networks operating out of equilibrium. Reproducing these dynamics synthetically demands precise control over kinetics, thermodynamics, and molecular design to convert energy inputs into time‐programmed function. Recent advances in stimuli‐responsive and chemically powered systems show how life‐like behaviors such as oscillations, autonomous motion, adaptive responses, and compartmentalization can be encoded using fuel‐driven cycles and stimulus‐gated switches powered by chemical, photonic, or enzymatic inputs. This mini‐review highlights molecular assemblies that sustain transient states, molecular machines powered by specific chemical inputs, responsive materials that reconfigure in response to environmental triggers, nucleic acid‐based networks for sensing and regulation, and artificial cells that exhibit compartmentalization and signaling. Together, these developments bridge systems chemistry and biomimicry, expanding the chemical toolkit for engineering matter that can adapt and respond. Beyond mimicking biology, such systems deepen our understanding of the molecular foundations of living matter and open new routes to technology. Self‐powered systems, molecular motors, smart materials, and artificial cells now form a rapidly growing toolbox with the potential to impact drug discovery, biosensing, energy, food production, and materials science. The field's future lies in integrating multiple life‐essential functions into a single construct, ultimately enabling synthetic systems that replicate the complex network behaviors of living organisms and inspire next‐generation innovation.
Sarabia‐Vallejo et al. (Sat,) studied this question.